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M9550182.TXT
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1995-03-04
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Document 0182
DOCN M9550182
TI Illness stage, concurrent medications, and other correlates of low
testosterone in men with HIV illness.
DT 9505
AU Wagner G; Rabkin JG; Rabkin R; New York State Psychiatric Institute,
College of Physicians and; Surgeons, Columbia University, New York
10032.
SO J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):204-7.
Unique Identifier : AIDSLINE MED/95136000
AB Our objective was to assess whether illness stage, markers of illness
progression, and use of medications believed to lower testosterone are
associated with low serum testosterone in HIV+ men. Data were available
for 234 HIV+ men screened for eligibility for a study of testosterone
replacement therapy and/or an antidepressant trial. A screening
interview was used to elicit demographic and medical information. Blood
was drawn to measure markers of immunodeficiency and serum testosterone.
Thirty-eight percent of the sample had testosterone levels below the
normal range. Low testosterone was associated with lower CD4 cell count,
later stage of illness, use of megestrol, and older age. Regression
analysis showed that only age and use of such medications as megestrol
were significant predictors of low testosterone. Given the prevalence of
low testosterone in HIV+ men and its link to sexual dysfunction, more
research is needed on treatments aimed at correcting or compensating for
this hormonal deficiency as well as the study of the impact of such
medications as megestrol on testosterone levels in older men.
DE beta 2-Microglobulin/ANALYSIS Adult Aged Antiviral Agents/THERAPEUTIC
USE Child Human HIV Infections/CLASSIFICATION/DRUG
THERAPY/*METABOLISM Male Middle Age Regression Analysis Support,
U.S. Gov't, P.H.S. T-Lymphocyte Subsets
Testosterone/*BLOOD/*DEFICIENCY Time Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).